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Search Results for " cathepsin s "

Targets Recommended: Cysteine Protease

18

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0116	LY 3000328 Cathepsin S inhibitor	Cysteine Protease	Proteases/Proteasome
	LY 3000328 (Cathepsin S inhibitor) 是 Cathepsin S 的选择性抑制剂，抑制人和小鼠Cat S 的IC50分别为7.7，1.67 nM。
T72569	Cathepsin L/S-IN-1
	CathepsinL/S-IN-1 是 Cathepsin L 和 Cathepsin S 的双重抑制剂，IC50分别为 4.10 μM 和 1.79 μM。CathepsinL/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。
T12051	MIV-247	Cysteine Protease	Proteases/Proteasome
	MIV-247 是一种具有选择性和高效性的 cathepsin S 抑制剂（人、小鼠和野猴 cathepsin S 的 Kis 分别为 2.1、4.2 和 7.5 nM），可减轻临床前神经性疼痛模型中的机械性异常性疼痛，可用于研究心肌损伤。
T6015	Cathepsin Inhibitor 1	Cysteine Protease	Proteases/Proteasome
	Cathepsin inhibitor 1 是Cathepsin 的选择性抑制剂，能够抑制CatL(pIC50:7.9)、CatL2(pIC50:6.7)、CatS(pIC50:6.0)、CatK(pIC50:5.5)和CatB(pIC50:5.2)。
T16089	MK-0674	Cysteine Protease	Proteases/Proteasome
	MK-0674 是一种可口服且具有选择性和高效性的 cathepsin K 抑制剂（IC50：0.4 nM），抑制 Cat B、Cat F、Cat L 和 Cat S，可用于和代谢相关的疾病。
T13288	VBY-825	Cysteine Protease	Proteases/Proteasome
	VBY-825是cathepsin 一种新型的可逆抑制剂，对cathepsin B, L, S 和V 都有很高的抑制力。
T3695	Pepstatin 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives; Proteasome; HIV Protease; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Pepstatin (Pepsin Inhibitor S 735A) 是由放线菌类产生的特异性天冬氨酸蛋白酶抑制剂，可抑制 HIV 蛋白酶的活性。
T1850	Balicatib AAE581,巴利卡替	Cysteine Protease	Proteases/Proteasome
	Balicatib (AAE581) 是组织蛋白酶K 抑制剂，其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。
T16092	L-873724	Others	Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively). L-873724 also shows an IC50 of
T11554	Cathepsin Inhibitor 2	Cysteine Protease	Proteases/Proteasome
	Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T16474	Petesicatib	Cysteine Protease	Proteases/Proteasome
	Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T35753	Z-Phe-Tyr(tBu)-diazomethylketone
	Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.
T27661	JNJ-10329670
	JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
T73220	RO5461111
	RO5461111 是一种高特异性、口服有效的Cathepsin S 拮抗剂 (IC50: 0.4 nM, humanCathepsin S ; 0.5 nM, murineCathepsin S)。RO5461111 能够有效抑制抗原特异性 T 细胞和 B 细胞活化。RO5461111 对肺部炎症和狼疮性肾炎有改善作用。
T80739	Z-FG-NHO-BzOME
	Z-FG-NHO-BzOME 是一种选择性半胱氨酸蛋白酶抑制剂，主要作用于组织蛋白酶 B、组织蛋白酶 L、组织蛋白酶 S 及木瓜蛋白酶。
T11864	Iptacopan LNP023	Others	Others
	Iptacopan (LNP023) 是一种与factor B 亲和力较高的抑制剂。
T73395	ASPER-29
	ASPER-29是一种Asperphenamate类似物，对组织蛋白酶L和S均显示出双重抑制作用，其IC50值分别为6.03 μM和5.02 μM。此化合物主要应用于癌症迁移和侵袭的研究。
T62494	Cathepsin C-IN-5
	CathepsinC-IN-5 (compound SF38) 为一高效、选择性、口服活性的组织蛋白酶 C (Cat C) 抑制剂，其针对Cat C、Cat L、Cat S、Cat B、Cat K 的IC50s 分别为 59.9 nM、4.26 µM、>5 µM、>5 µM、>5 µM。该化合物能够抑制骨髓和血液中的Cat C活性，降低中性粒细胞丝氨酸蛋白酶（NSP）的激活，并展现抗炎活性。

化合物

Cat.No: TQ0116

Synonym: Cathepsin S inhibitor

Target: Cysteine Protease

Cathepsin L/S-IN-1

Cat.No: T72569

Cat.No: T12051

Target: Cysteine Protease

Cathepsin Inhibitor 1

Cat.No: T6015

Target: Cysteine Protease

Cat.No: T16089

Target: Cysteine Protease

Cat.No: T13288

Target: Cysteine Protease

Cat.No: T3695

Synonym: 抑肽素,Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C

Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy

Cat.No: T1850

Synonym: AAE581,巴利卡替

Target: Cysteine Protease

Cat.No: T16092

Target: Others

Cathepsin Inhibitor 2

Cat.No: T11554

Target: Cysteine Protease

Cat.No: T16474

Target: Cysteine Protease

Z-Phe-Tyr(tBu)-diazomethylketone

Cat.No: T35753

Cat.No: T27661

Cat.No: T73220

Cat.No: T80739

Cat.No: T11864

Synonym: LNP023

Target: Others

Cat.No: T73395

Cathepsin C-IN-5

Cat.No: T62494

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00735	Cathepsin S Protein, Human, Recombinant (His) cathepsin S,MGC3886,CTS<...	Human	HEK293 Cells
	Cathepsin S Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P25774-1.
TMPY-02751	Cathepsin S Protein, Mouse, Recombinant (His) cathepsin S,Cat S,Cat	Mouse	HEK293 Cells
	Cathepsin S Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is AAB94925.1.
TMPY-00362	Cathepsin S Protein, Rat, Recombinant (His) CTSS,Cathepsin S	Rat	HEK293 Cells
	Cathepsin S Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa.
TMPY-02450	Cathepsin D Protein, Human, Recombinant (His) HEL-S-130P,CLN10,cathepsin D,CP	Human	HEK293 Cells
	Cathepsin D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P07339.
TMPY-01249	Cathepsin V Protein, Human, Recombinant (His) CTSV,cathepsin V,MGC125957,CATL2,...	Human	HEK293 Cells
	Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other mem...
TMPY-01644	Cystatin S Protein, Human, Recombinant (His) MGC71923,cystatin S,CST4	Human	HEK293 Cells
	Cystatin-S, also known as Cystatin-4, Salivary acidic protein 1, Cystatin-SA-III and CST4, is a secreted protein which belongs to thecystatin family. Cystatin-4 / CST4 is expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). It is also expressed in saliva, tears, urine and seminal fluid. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while oth...
TMPY-00729	Cystatin D Protein, Human, Recombinant (His) CST5,MGC71922,cystatin D	Human	HEK293 Cells
	Cystatins are natural inhibitors of papain-like (family C1) and legumain-related (family C13) cysteine peptidases. The mammalian cystatin superfamily members are of three major types, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. As a member of type 2 cystatin, cystatin D is a single-domain protein and also has cysteine residues that form disulfide bridges. In contrast with the wider distribution of all the other family 2 cystatins, cystatin D is tissue-restricte...

重组蛋白

Cathepsin S Protein, Human, Recombinant (His)

Cat.No: TMPY-00735

Species: Human

Expression System: HEK293 Cells

Cathepsin S Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02751

Species: Mouse

Expression System: HEK293 Cells

Cathepsin S Protein, Rat, Recombinant (His)

Cat.No: TMPY-00362

Species: Rat

Expression System: HEK293 Cells

Cathepsin D Protein, Human, Recombinant (His)

Cat.No: TMPY-02450

Species: Human

Expression System: HEK293 Cells

Cathepsin V Protein, Human, Recombinant (His)

Cat.No: TMPY-01249

Species: Human

Expression System: HEK293 Cells

Cystatin S Protein, Human, Recombinant (His)

Cat.No: TMPY-01644

Species: Human

Expression System: HEK293 Cells

Cystatin D Protein, Human, Recombinant (His)

Cat.No: TMPY-00729

Species: Human

Expression System: HEK293 Cells

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